Heather(Hua-Shan) Liu

Assistant Professor

About Me

Heather (Hua-Shan) Liu received her Ph.D. in Electrical Engineering in 2008 from the National Taiwan University, Taipei, Taiwan under the mentorship of Dr. Hsiao-Wen Chung. Her thesis work examined the parenchymal enhancement patterns for ischemic patients with spontaneous reperfusion phenomenon using a perfusion-based pharmacokinetic model. From fall 2005 to summer 2008, she also worked in the Department of Radiology at Tri-Service General Hospital, Taipei, Taiwan as a medical physicist under Dr. Cheng-Yu Chen to develop MRI-related data analysis algorithms in clinical MRI application projects. In 2008 she took a three-year post-doctoral fellow position at the Neuroimaging Research Branch at the National Institute on Drug Abuse (NIDA), Baltimore, USA where she worked under Drs. Elliot Stein and Yihong Yang investigating the changes in brain tissue integrity following a rat stroke model using multimodal MRI techniques. In a separate set of studies to explore questions in the field of drug addiction, she applied functional MRI in a rat self-administration model of cocaine abuse to investigate the neural response to drug-associated cues. In 2011, she took a two-year post-doctoral fellow position at the Center for Functional Neuroimaging at the University of Pennsylvania, Philadelphia, USA where she worked under Dr. John Detre using arterial spin labeled perfusion MRI to investigate the relationship between cerebral blood flow and physiological parameters in children with chronic kidney disease and autism spectrum disorder. She is currently an Assistant Professor at the Imaging Research Center, Department of Medical Imaging, Graduate Institute of Clinical Medicine at the Taipei Medical University Hospital at the Taipei Medical University, Taipei, Taiwan.

Research Interests

fMRI
Neuroimaging

Awards

Student Stipend for the 18th Annual Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM), Stockholm, SWEDEN, 2010

National Science Council Stipend for the Postdoctoral Research Abroad Program, Taipei, Taiwan, 2008

Outstanding Students Conference Travel Grant of the Foundation for the Advancement of Outstanding Scholarship to attend the 16th Annual Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM), Toronto, CANADA, 2008

Ministry of Education Stipend for the 15th Annual Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM), Berlin, GERMANY, 2007

Student Stipends for the 15th Annual Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM), Berlin, GERMANY, 2007

National Science Council Stipends for the 14th Annual Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM), Seattle, U.S.A., 2006

Student Stipends for the 14th Annual Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM), Seattle, U.S.A., 2006

Work Experience

Assistant Professor, Department of Medical Imaging, Graduate Institute of Clinical Medicine Taipei Medical University, Taipei, Taiwan

June 2014 - Present

Research fellow, Department of Medical Imaging, Taipei Medical University Hospital, Taipei

December 2013 - Present

Postdoctoral Fellow, Department of Neurology, Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, Pennsylvania

November 2011 - 2013

Postdoctoral Fellow, Neuroimaging Research Branch, Intramural Research Program of the National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland

November 2008 - 2011

Medical Physicist, Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan

April 2005 - September 2008

Research Assistant, Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan

August 2001 - July 2002


Invited Talk

October, 2015: Basic MR physics, educational course for clinical residents, RSROC, Taipei Veterans General Hospital, RSROC, Taiwan


January, 2015: Clinical application of pharmacokinetic model in MR perfusion-weighted imaging, CSMRS-5 & 2015 TMRS Annual Meeting, National Cheng Kung University, Tainan, Taiwan


October, 2014: Cerebral perfusion-weighted imaging, Tri-Service General Hospital, Taipei, Taiwan


February, 2012: Potential long-term effects of MDMA on the basal ganglia-thalamocortical circuit: a proton MR spectroscopy and diffusion-tensor imaging study, National Sun Yat-sen University, Kaohsiung, Taiwan


August, 2011: Neural response to drug-associated odor cues in rats exposed to long-access cocaine self-administration, University of Pennsylvania, Philadelphia, PA, USA


April, 2010: Translational imaging to understand stroke, Taipei Medical University, Taipei, Taiwan


Publications

Cerebral Microbleeds and Iron Depletion of Dentate Nuclei in Ataxia-Telangiectasia.

Liu HS, Chen YC, Chen CY. Neurology. 2016 (accepted)

Read

Post-treatment with Cocaine- and Amphetamine-regulated Transcript Enhances Infarct Resolution, Reinnervation and Angiogenesis in Stroke Rats - A Magnetic Resonance Imaging Study.

Liu HS, Shen H, Luo Y, Hoffer BJ, Wang Y, Yang Y. NMR Biomed. 2016; 29: 361–370.

Read

High Agatston Calcium Score of Intracranial Carotid Artery: A Significant Risk Factor for Cognitive Impairment.

Kao HW, Liou M, Chung HW, Liu HS, Tsai PH, Chiang SW, Chou MC, Peng GS, Huang GS, Hsu HH, Chen CY. Medicine (Baltimore). 2015 Sep;94(39):e1546.

Read

Design and Methods of the NiCK Study: Neurocognitive Assessment and Magnetic Resonance Imaging Analysis of Children and Young Adults with Chronic Kidney Disease.

Hartung EA, Laney N, Kim JY, Ruebner RL, Detre JA, Liu HS, Davatzikos C, Erus G, Doshi JJ, Schultz RT, Herrington JD, Jawad AF, Moodalbail DG, Gur RC, Port AM, Radcliffe J, Hooper SR, Furth SL. BMC Nephrol. 2015 Apr 30;16(1): 66.

Read

Effects of Microvascular Permeability Changes on Contrast-Enhanced T1 and Pharmacokinetic MR Imagings after Ischemia.

Hua-Shan Liu, Hsiao-Wen Chung, Ming-Chung Chou, Michelle Liou, Chao-Ying Wang, Hueng-Wen Gao, Shih-Wei Chiang, Chun-Jung Juan, Guo-Shu Huang, Cheng-Yu Chen. STROKE. 44(7):1872-1877, Jul 2013.

Read

Systematic review of structural and functional neuroimaging findings in children and adults with CKD.

Moodalbail DG, Reiser KA, Detre JA, Schultz RT, Herrington JD, Davatzikos C, Doshi JJ, Erus G, Liu HS, Radcliffe J, Furth SL, Hooper SR. Clin J Am Soc Nephrol. 2013 Aug;8(8):1429-48.

Read

Dorsolateral caudate nucleus differentiates cocaine from natural reward-associated contextual cues.

Liu HS, Chefer S, Lu H, Guillen K, Rea W, Kurup P, Yang Y, Peoples L, Stein EA. Proc Natl Acad Sci U S A. 2013 Feb;33(2):300-10.

Read

CART peptide induces neuroregeneration in stroke rats.

Luo Y, Shen H, Liu HS, Yu SJ, Reiner DJ, Harvey BK, Hoffer BJ, Yang Y, Wang Y. J Cereb Blood Flow Metab. 2013 Feb;33(2):300-10.

Read

Potential long-term effects on the basal ganglia-thalamocortical circuit in MDMA (Ecstasy) users: a proton MRS and diffusion tensor imaging study.

Liu HS, Chou MC, Chung HW, Chuo NY, Chiang SW, Wang CY, Juan CJ, Gao HW, Huang GS, Chen CY. Radiology. 2011 Aug;260(2):531-40.

Read

Post-treatment with amphetamine enhances reinnervation of the ipsilateral side cortex in stroke rats.

Liu HS, Shen H, Harvey BK, Castillo P, Lu H, Yang Y, Wang Y. Neuroimage. 2011 May;56(1):280-9.

Read

Idiopathic growth hormone deficiency in the morphologically normal pituitary gland is associated with perfusion delay.

Wang CY, Chung HW, Cho NY, Liu HS, Chou MC, Gao HW, Juan CJ, Lee MS, Huang GS, Chen CY. Radiology. 2011 Jan;258(1):213-21.

Read

Salivary glands: echo-planar versus PROPELLER diffusion-weighted MR imaging for assessment of ADCs.

Juan CJ, Chang HC, Hsueh CJ, Liu HS, Huang YC, Chung HW, Chen CY, Kao HW, Huang GS. Radiology. 2009 Oct;253(1):144-52.

Read

Quantification of non-water-suppressed MR spectra with correction for motion-induced signal reduction.

Lin JM, Tsai SY, Liu HS, Chung HW, Mulkern RV, Cheng CM, Yeh TC, Chen NK. Magn Reson Med. 2009 Dec;62(6):1394-403.

Read

T2-enhanced tensor diffusion trace-weighted image in the detection of hyper-acute cerebral infarction: comparison with isotropic diffusion-weighted image.

Chou MC, Tzeng WS, Chung HW, Wang CY, Liu HS, Juan CJ, Lo CP, Hsueh CJ, Chen CY. Eur J Radiol. 2010 Jun;74(3):e89-94.

Read

Volume-dependent overestimation of spontaneous intracerebral hematoma volume by the ABC/2 formula.

Wang CW, Juan CJ, Liu YJ, Hsu HH, Liu HS, Chen CY, Hsueh CJ, Lo CP, Kao HW, Huang GS. Acta Radiol. 2009 Apr;50(3):306-11.

Read

Perfusion characteristics of late radiation injury of parotid glands: quantitative evaluation with dynamic contrast-enhanced MRI.

Juan CJ, Chen CY, Jen YM, Liu HS, Liu YJ, Hsueh CJ, Wang CY, Chou YC, Chai YT, Huang GS, Chung HW. Eur Radiol. 2009 Jan;19(1):94-102.

Read

Anomalous J-modulation effects on amino acids in clinical 3T MR spectroscopy.

Liu HS, Chung HW, Juan CJ, Tsai SY, Wang CY, Chan CC, Huang GS, Chou MC, Lee CS, Ko CW, Cho NY, Chen CY. AJNR Am J Neuroradiol. 2008 Oct;29(9):1644-8.

Read

Pseudolesions arising from unfolding artifacts in diffusion imaging with use of parallel acquisition: origin and remedies.

Chou MC, Wang CY, Liu HS, Chung H-W, Chen C-Y, AJNR Am J Neuroradiol. 2007 Jun-Jul;28(6):1099-101.

Read

Frequency stabilization using infinite impulse response filtering for SSFP fMRI at 3T.

Wu ML, Wu PH, Huang TY, Shih YY, Chou MC, Liu HS, Chung HW, Chen CY. Magn Reson Med. 2007 Feb;57(2):369-79.

Read

Inclusion of biological factors in parallel-architecture normal-tissue complication probability model for radiation-induced liver disease.

Cheng JCH, Liu HS, Wu JK, Chung HW, Jan GJ. Int J Radiat Oncol Biol Phys. 2005 Jul;62(4):1150-6.

Read

Biologic susceptibility of hepatocellular carcinoma patients treated with radiotherapy to radiation-induced liver disease.

Cheng JCH, Wu JK, Lee PCT, Liu HS, Jian JJM, Lin YM, Sung JL, Jan GJ. Int J Radiat Oncol Biol Phys. 2004 Dec;60(5):1502-9.

Read

Dosimetric analysis and comparison of three-dimensional conformal radiotherapy and intensity-modulated radiation therapy for patients with hepatocellular carcinoma and radiation-induced liver disease.

Cheng JCH, Wu JK, Huang CM, Liu HS, Huang DY, Tsai SY, Cheng SH, Jian JJM, Huang AT. Int J Radiat Oncol Biol Phys. 2003 May;56(1):229-34.

Read

Radiation-induced liver disease after three-dimensional conformal radiotherapy for patients with hepatocellular carcinoma: dosimetric analysis and implication.

Cheng JCH, Wu JK, Huang CM, Liu HS, Huang DY, Cheng SH, Tsai SY, Jian JJM, Lin YM, Cheng TI, Horng CF, Huang AT. Int J Radiat Oncol Biol Phys. 2002 Sep;54(1):156-62.

Read